M3D Inc Awarded NSF SBIR Phase I Grant for Advanced Gamma Camera Design

M3D Inc. has secured a $275,000 SBIR Phase I award from the National Science Foundation (NSF) to advance its research on gamma camera designs aimed at improving sentinel lymph node biopsies, particularly in tough-to-navigate head and neck cancer cases.

Surgeons often face a challenge when a lymph node is too close to the tumor. Radiotracers such as Technetium-99 are injected into the tumor during a biopsy to help locate connected lymph nodes. However, in cases where the lymph node is near the tumor, the nearby radiation injection overwhelms traditional detection methods, like Geiger counter pens, making it difficult for surgeons to identify and target impacted lymph nodes accurately.

With this NSF funding, plus $25,000 in matching funds from the state of Michigan, M3D is working on a tungsten-based mask designed to selectively block radiation from the primary tumor while allowing precise imaging of nearby lymph nodes. This solution is optimized to improve accuracy in lymph node detection, reducing the risk of missing critical lymph nodes and improving overall outcomes for patients with cancer.

Ann Arbor-based M3D has built a reputation for its high-resolution 3D CZT (cadmium zinc telluride) gamma cameras, and this project aims to redefine how surgeons handle complex cases in real-time.

In addition to their research efforts, M3D recently launched its first commercial product, the RAVIN CAM, with initial deliveries set for the end of the year. This safety camera will be deployed in hospitals and healthcare facilities to detect and mitigate radiation contamination.

Receiving this highly competitive NSF grant—awarded to fewer than 10% of applicants—recognizes M3D’s leadership in medical imaging and its commitment to creating practical tools that make a real difference in healthcare.